Interestingly, miR-21/29b/126/148, which are overexpressed in CD4+ T cells from SLE patients, downregulate DNMT1 (373–375), while miR-199a-5p increased splenic CD4+ T cell senescence by inhibiting SIRT1 and thus increasing the acetylation and consequently the activation of p53 (376). The gene discussed is CD4; the disease is systemic lupus erythematosus.