CD8A and cancer: Immunosenescence has been implicated in reduced defenses against infections and reduced response to vaccination (due to a reduced antigenic response by T and B cells), an increased risk of cancer (due to an imbalance between the function of regulatory cells and cytotoxic CD8+ T cells) and auto-immune diseases (due to reduced clearance of apoptotic cells and reduced antibody diversity, with however an increased susceptibility to molecular mimicry) (27–30).