Studies at home and abroad have found that the expression of pvt1 is upregulated in patients with chronic myeloid leukemia, and studies have shown that [20] pvt1 silencing leads to cell cycle arrest by negatively regulating the expression of cell cycle-dependent kinase inhibitors p15 and p16, so as to inhibit the growth of tumor cells. The gene discussed is PVT1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.