The potential mechanism of this effect might be related to mitochondrial energy metabolism, and it can be mediated by MCU in AHF rats induced by propafenone hydrochloride (Zhang et al., 2017) and improved by the liver kinase B1 (LKB1)/AMPKα/SIRT1 signaling pathway in doxorubicin (DOX)-induced CHF rats (Wen et al., 2020b), (Table 3). Here, STK11 is linked to congestive heart failure.