In models of cardiac I/R injury, pharmacological agent-induced cardiotoxicity, obesity, long-term nicotine intake, and diabetes, Resveratrol activates the antioxidant genes such as those encoding HO-1, SOD, CAT, and glutathione (GSH), which can help to promote the balance between oxidative stress and antioxidants, especially in the mitochondria (Kovacic and Somanathan, 2010; Li et al., 2012; Ahmad and Hoda, 2020; Ramalingam et al., 2021). The gene discussed is HMOX1; the disease is diabetes mellitus.