Besides, the mutation of LMN gene also elicits a dozen of diseases, including FPLD, Hutchinson–Gilford progeria syndrome (HGPS), metabolic associated fatty liver disease (MAFLD), MAD, dilated cardiomyopathy (DCM), autosomal dominant leukodystrophy (ADLD), acquired partial lipodystrophy (APL), Barraquer–Simons (BSS) syndrome, atypical Werner syndrome (WS), limb girdle muscular dystrophy type 1b (LGMD1B), and the autosomal dominant form of Emery–Dreifuss muscular dystrophy (AD-EDMD). The gene discussed is LMNB1; the disease is adult-onset autosomal dominant demyelinating leukodystrophy.