LMNA and metabolic disease: FPLD2, a large genetic and phenotypic variation first reported in the 1970s, is characterized by the progressive loss of subcutaneous adipose tissue in the limbs and trunk, accumulation of fat in the face and neck, and severe metabolic disorders, including insulin resistance, glucose intolerance, diabetes, dyslipidemia, and steatohepatitis (Dunnigan et al., 1974; Köbberling et al., 1975; Krawiec et al., 2016).