LMNA and lipodystrophy: More intriguingly, the pathogenesis of HGPS is caused by the LMNA mutation, preventing the conversion of prelamin A to mature lamin A, thereby leading to the accumulation of prelamin A. Later, a large number of studies reported the pathogenesis of lipodystrophy in FPLD roots in the accumulation of prelamin A by mutated LMNA, which is similar to the pathogenesis of HGPS (Capanni et al., 2005; Bidault et al., 2013; Afonso et al., 2016).