Regarding the neuroinflammatory processes largely described in the 5xFAD mice and in human subjects with AD (Oakley et al., 2006; Heneka et al., 2015), it is worth mentioning that GSK3β activation has been associated with increases in neuroinflammation such as astrogliosis and microglial activation (Wang et al., 2010; Ko et al., 2014). Here, GSK3B is linked to Alzheimer disease.