AD pathology starts in structures such as the hippocampus and the entorhinal cortex (DeTure and Dickson, 2019; Long and Holtzman, 2019), being the extracellular amyloid-β (Aβ) plaques and intracellular tangles of abnormally hyperphosphorylated Tau the most representative AD hallmarks (DeTure and Dickson, 2019). This evidence concerns the gene MAPT and Alzheimer disease.