Moreover, SGLT2 inhibitors rarely cause diuresis-related electrolyte abnormalities, such as hypokalaemia, hypomagnesemia, and hyperuricemia, suggesting that SGLT2 inhibitors lower BP by other methods in addition to “diuresis,” which may be secondary to reduced arterial stiffness and improved endothelial function. This evidence concerns the gene SLC5A2 and familial primary hypomagnesemia.