However, the activity of HIF signaling in diabetic kidney is still controversy with one study reported tubule-specific knockout of HIF-1α aggravated kidney dysfunction and renal histopathological alterations in streptozotocin-induced diabetic mice (Jiang et al., 2020), and another elegant study, on the contrary, found that a specific inhibitor of HIF-1 attenuates the manifestations of diabetic nephropathy in OVE26 type 1 diabetic mice (Nayak et al., 2016). The gene discussed is HIF1A; the disease is diabetic kidney disease.