AGT and hypertensive disorder: Our data showed that under roxadustat administration in murine Ang II-induced hypertension models, the expression of Ang II Receptor Type 1 (AGTR1), which impacts constricting vessels and reabsorbing salt and water, was decreased, while the expression of both AGTR2, a receptor that shows the opposite function to AGTR1, and endothelial nitric oxide (eNOS), which regulates the vascular tone of the small artery, was upregulated.