FOXO3 and neoplasm: PHDs altered the expression of Akt (Guo et al., 2016), centrosomal protein Cep192 (Moser et al., 2013) and FOXO3a (Zheng et al., 2014) to regulate cell proliferation and viability, and showed their potential contribution to tumor development and metastasis via the changes of F-actin (Luo et al., 2014), NFκB (Cummins et al., 2006) or Sprouty2 (Anderson et al., 2011).