Miao et al. (2021) found that roxadustat could suppress the release of inflammatory factors in the model of renal I/R-induced injury mice whose observation period is 2 days. While our group found roxadustat posed no effect on the level of TNF-α and IL-6 in serum and heart of doxorubicin-induced mice (Long et al., 2020; Wu et al., 2021). In experimental colitis, Higashiyama et al. (2012) reported that stimulation of HIF-1 exacerbates inflammatory cell infiltration in experimental colitis. This evidence concerns the gene TNF and colitis.