Among SLs family, we chose ALT and Brv-A (Figures 2A,B) for the current study, as 1) the anti-cancer effect and their pivotal role in the inhibition of STAT3 signaling has been extensively reported 2) we confirmed that STAT3, FUT4, and P-GP were the common targets of ALT and Brv-A. This evidence concerns the gene STAT3 and cancer.