KRAS and neoplasm: However, recently, covalent inhibitors targeting specific KRAS mutations - glycine 12 to cysteine (G12C) have been developed, providing an unprecedented opportunity to directly target KRAS and showing encouraging preclinical efficacy in KRAS-G12C tumor models (Patricelli et al., 2016; Fell et al., 2018; Janes et al., 2018).