GLP1R and depressive disorder: A pooled analysis on 5,325 individuals with higher BMI without diabetes evaluating the effectiveness of trials using GLP1-RA for 32–160 weeks also found no significant differences in depression (2.1 versus 2.1 events/100 person-years) and anxiety (1.9 versus 1.7 events/100 person-years) (O'Neil et al., 2017).