This may be another reason why GLP1-RA users not using DPP-4 inhibitors had better reduction of anxiety, since when the patient needs to pay for the other hypoglycemic agent, it may indicate that his or her glucose control is poorer, and may have more anxiety regarding health conditions compared to those who did not combine DPP-4 inhibitor with GLP1-RA. This evidence concerns the gene GLP1R and Anxiety.