There is evidence that ECH also decreases IL-6 expression in the MPTP-induced PD mice (Zhang et al., 2021), ischemia/reperfusion injured rat (Li et al., 2018b), and cervical spondylotic myelopathy rat model (Zhou et al., 2020) and significantly diminishes IL-6 level in 6-OHDA-treated PC12 cells (Wang YH et al., 2015) and lipopolysaccharides- (LPS-) induced BV2 cells (Zhou et al., 2020). The gene discussed is IL6; the disease is Parkinson disease.