Reportedly, transient amounts of ECH can heighten TrkA/TrkB activity and increase NGF/BDNF in rotenone-treated primary rat cortical neurons (Zhu et al., 2013), and ECH initiates a rise in BDNF in the SN of MPTP-induced PD mice (Zhang et al., 2021). Here, BDNF is linked to Parkinson disease.