FGFR4 and neoplasm: In vivo studies demonstrated that the most potent one of the N-lobe-targeting immunotoxins, J80A-PE24, could transiently control Hep3B tumor growth in NSG (NOD, Prkdcscid, IL2rg null) mice, which was further significantly boosted through combination with FGF401, a clinically testing fibroblast growth factor receptor 4 (FGFR4) inhibitor that has activity of multiple tyrosine kinase-inhibition and anti-angiogenesis, leading to a much longer survival time of the treated mice.