Similarly, it has been reported that complexing extracellular DNA with peptides such as LL-37 enhances DNA up-take into living cells in cancers and psoriasis33 suggesting that NETs-protein was necessary to the internalization of NETs into HCC cells and the subsequent enhanced activation of tumorous pro-inflammatory signaling by the enriched oxidized mtDNA content in HCC-NETs. The gene discussed is CAMP; the disease is hepatocellular carcinoma.