The Cox regression model showed that the RIOK1 expression level (hazard ratio 8.23; 95% confidence interval CI 0.239-0.764, P=0.004), pathologic stage (hazard ratio 6.191; 95% CI 0.308-0.869, p=0.013), and tumor size (hazard ratio 14.082; 95% CI 1.135-1.495, p<0.001) were independent prognostic factors for the poor overall survival of NSCLC patients. This evidence concerns the gene RIOK1 and neoplasm.