The RIOK1 has been reported to be over-expressed in gastric adenocarcinoma, cecal adenocarcinoma, colorectal adenoma, and colorectal adenocarcinoma, suggesting that RIOK1 engages in a functional relationship with constitutively active RAS to regulate the tumor cell malignancy 14. The gene discussed is RIOK1; the disease is colorectal adenocarcinoma.