In addition, expression levels for TEX11, C4orf19, CLCA1 and CA2 were low-regulated in COAD patients with lymph node metastases, while NOTCH 3 was up-regulated in these patients (Figure 6B). In addition, both TEX11 and C4orf19 expression levels were low-regulated in COAD patients with distant metastases (Figure 6C). This evidence concerns the gene CLCA1 and metastatic malignant neoplasm in the lymph nodes.