Kang et al. 32 showed that FAK can regulate Y-box binding protein 1-mediated paclitaxel resistance in ovarian cancer; activated FAK is found in doxorubicin-resistant MCF-7/Dox cells compared with parental MCF-7 cells 35; FAK overexpression can upregulate alcohol dehydrogenase and X-linked inhibitor of apoptosis protein activity in platinum-resistant ovarian cancer cells 36. This evidence concerns the gene AKR1A1 and ovarian cancer.