Treatment of GC cells with TFP and BAPTA/AM showed that HRC-induced Raf/MEK/ERK phosphorylation depends on Ca2+/CaM signals to regulate EMT in GC Finally, by constructing a subcutaneous tumor model and an abdominal cavity implant model, we found that HRC can promote tumor growth and proliferation in nude mice. This evidence concerns the gene MAP2K7 and neoplasm.