SOD1 and obesity due to melanocortin 4 receptor deficiency: However, there was a greater proportion of female patients, older adults (≥ 65 years), overweight and obesity patients, laparoscopic surgery, carcinoma of the rectum (vs right or left colon cancer), signet-ring cell carcinoma (vs adenocarcinoma or mucinous adenocarcinoma), CRM+, combined anesthesia (GA+EA), and ASA III-V (vs I or II) in the LOD group compared with the SOD group (P<0.05).