FLI1 and breast cancer: For example, FECR1, a circRNA derived from exons 2, 3, and 4 of the FLI1 gene, could bind to the promoter of FLI1 and then activate FLI1 by inducing DNA hypomethylation in CpG islands of the promoter, thus promoting the metastasis of breast cancer (Chen et al., 2018).