GSDME and neoplasm: It was also reported that upregulation of GSDME in tumor cells increased the infiltration of NK cells and antigen-specific CD8+ T lymphocytes, enhanced the secretion of antitumor effectors in tumor-infiltrating lymphocytes (TILs), and promoted tumor-associated macrophage-mediated phagocytosis of tumor cells (Tsuchiya, 2021).