Chen Q. et al. (2021) found that lncRNA TMEM161B-AS1 mediated by HSA-Mir-27a-3p had an inhibitory effect on glioma cells, and hsa-Mir-27a-3p inhibited the proliferation, migration, and invasion of glioma cells by down-regulating the expression of FANCD2 and CD44, thus promoting cell apoptosis and ferroptosis. This evidence concerns the gene CD44 and central nervous system cancer.