We found that five radiomic features, including one texture feature (Original.GLCM.Contrast), two wavelet-transformed texture features (Wavelet_LHH.GLCM.ClusterShade and Wavelet_LLH.GLSZM.SmallAreaEmphasis), and two wavelet-transformed first-order features (Wavelet_HLH.Firstorder.Maximum and Wavelet_LLL.Firstorder.Skewness), were independent predictors of BM in patients with ALK-rearranged NSCLC. Here, ALK is linked to non-small cell lung carcinoma.