PTTG1 and cancer: Interestingly, the expression of PTTG1 was lower in cancer than corresponding normal tissue in LAML and TGCT (Supplementary Figure S2), which might mean the PTTG1 would be a “double-edged sword” for the PTTG1 was oncogene in most of tumors but also tumor suppressor gene in tumors such as LAML and TGCT.