CLDN22 and colorectal carcinoma: Gaedcke et al. (2010) found fold-change values for the expression of CLDN1, CLDN10, CLDN11, CLDN15, and CLDN22 of 19.563, 1.583, 1.718, 1.417, and 1.05, respectively, in READ tissues. Skrzypczak et al. (2010) further reported CLDN1 and CLDN2 expression levels in CRC tissues that were altered by 6.351- and 7.754-fold, respectively.