P53 signaling pathway, DNA replication, ECM-receptor interaction, TGF-beta signaling pathway, chemokine signaling pathway, MAPK signaling pathway, cell cycle, and other signaling pathway are known to be involved in cancer (Constanzo et al., 2016; Zhan et al., 2017; Becker et al., 2019; Tsukita et al., 2019; Chi et al., 2020; Shen et al., 2020; Nozaki and Nishizuka, 2021). The gene discussed is TP53; the disease is cancer.