The risk model was associated with ECM-receptor interaction, cytokine-cytokine receptor interaction, MAPK, and other signaling pathways involved in the progression of NSCLC, and identified relationships with macrophages M0, Tfh, Tregs, etc. The nomogram and the risk model constructed on the basis of MSC-related factors POSTN, TRPA1 and DDIT4 could facilitate the search for target molecules involved in the progression of NSCLC, and the risk model could help in the evaluation of the prognosis of NSCLC patients. This evidence concerns the gene TRPA1 and non-small cell lung carcinoma.