SEPTIN9 and cancer: Meanwhile, as a cell cycle-related protein, SEPT9 has been confirmed to be involved in tumorigenesis and development in a variety of malignant tumors, and the methylation detection of SERT9 gene in peripheral blood has high sensitivity and specificity for the diagnosis of CRC, and can be used in early CRC screening, it may be a useful biomarker for the prognosis of CRC (Mostowy and Cossart 2012; Sun et al., 2019; Yang et al., 2019).