In recent years, with the progress of tumor molecular biology research, more and more new and effective markers have been discovered, for example, Ritwik Patra’s research found that COL11A1 gene mutation profoundly affects the occurrence and development of colorectal cancer, and confirmed the qualification of COL11A1 gene as a potential biomarker for colorectal cancer prognosis (Patra et al., 2021). Here, COL11A1 is linked to colorectal cancer.