It was observed that the GNG7 expression was up-regulated in kidney cancer, leukemia and lung cancer compared with the normal tissues, while it was down-regulated significantly in some datasets of bladder cancer, brain and CNS cancer, breast cancer, colorectal cancer, gastric cancer, head and neck cancer, leukemia, lymphoma, ovarian cancer and pancreatic cancer (Figure 3A, Supplementary Table S1). This evidence concerns the gene GNG7 and familial pancreatic carcinoma.