However, the expression of TMPRSS2 in breast invasive cancer (BRCA), esophageal cancer (ESCA), head and neck squamous cell carcinoma (HNSC), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), rectal adenocarcinoma (READ), sarcoma (SARC), skin cutaneous melanoma (SKCM), testicular germ cell tumor (TGCT), and thyroid cancer (THCA), including lung squamous cell carcinoma (LUSC), was downregulated (Figure 4). This evidence concerns the gene TMPRSS2 and esophageal cancer.