The formula for calculating the Ras-score for each ESCC patient is as follows: Ras − score = −0.027390631097796 ∗ EGFR − 0.250341831449203 ∗PDGFRA + 0.0669651154761456∗RAP1B. The gene discussed is EGFR; the disease is esophageal squamous cell carcinoma.