The role of TBX22 during palatogenesis was confirmed in experiments using Tbx22null mice, which presented with submucous CP, ankyloglossia, severely underdeveloped vomer, and choanal atresia, caused by reduced bone formation in the posterior hard palate due to impaired ossification (Pauws et al., 2009). This evidence concerns the gene TBX22 and ankyloglossia.