TBX22 has been described in several previous studies (Braybrook et al., 2001; Marçano et al., 2004; Demeer et al., 2018) as a cause of X-linked semi-dominant CP and ankyloglossia (CPX) (OMIM). The gene discussed is TBX22; the disease is cleft palate with or without ankyloglossia, X-linked.