Of the seven genes comprising our prognostic signature, the expressions of ATMIN, ZNF438, and ZNF597 were lower in the high-risk group, and lower expressions of ATMIN, ZNF438, and ZNF597 predicted worse overall survival in patients with osteosarcoma, suggesting that ATMIN, ZNF438, and ZNF597 might act as protective factors in osteosarcoma. The gene discussed is ATMIN; the disease is osteosarcoma.