We observed that miR-208b regulates the conversion of muscle fibers to slow muscle by targeting and inhibiting Mettl8 while Mettl8 can in turn affect the host gene Myh7 encoding miR-208b, thus forming a regulatory network which is similar to the regulatory network of miR-499 and its target gene Sox6 in a previous study using a mouse model of skeletal muscle atrophy (Mccarthy et al., 2009). Here, SOX6 is linked to muscular atrophy.