Consequently, microtubule poisons that either destabilize microtubules such as vincristine or aberrantly stabilize microtubule such as the taxane paclitaxel are used to treat cancer by triggering the SAC, which in turn triggers mitotic catastrophe and cell death in rapidly dividing cancer cells (Mukhtar et al., 2014; Yasuhira et al., 2016). Here, ADCY10 is linked to cancer.