For example, ELK1 Thr-417 phosphorylation triggers apoptosis in neurons and in neurodegenerative disease such as Lewy body disease, Alzheimer’s disease and Huntington’s disease, and phosphorylated ELK1 (positive for Thr-417) is found in the different protein inclusions/aggregates associated with these disease (Sharma et al., 2010). Here, ELK1 is linked to early-onset autosomal dominant Alzheimer disease.