For example, ELK1 Thr-417 phosphorylation triggers apoptosis in neurons and in neurodegenerative disease such as Lewy body disease, Alzheimer’s disease and Huntington’s disease, and phosphorylated ELK1 (positive for Thr-417) is found in the different protein inclusions/aggregates associated with these disease (Sharma et al., 2010). The gene discussed is ELK1; the disease is Alzheimer disease.