PRP4K and neoplasm: For example, trifluridine-induced CIN was shown to impair triple negative breast cancer (TNBC) tumour growth (Li et al., 2020), and at least one study has linked depletion of PRP4K in the MDA-MB-231 xenograft model of TNBC to reduced metastasis in mice (Koedoot et al., 2019).