PTPN11 and psoriasis: Since neutrophils have increased in patients with psoriasis, and SHP2 inhibition can alleviate psoriasis, we crossed Shp2flox/flox mice with S100a8cre mice and constructed Cre‐driven SHP2 deletion in neutrophils: S100a8cre‐Shp2flox/flox (SHP2N KO) mice and Shp2flox/flox (SHP2N WT) mice to further study the role of SHP2 in psoriasis.