NR3C1 and early-onset autosomal dominant Alzheimer disease: Overall, the roles that MR activation is predicted to play in attention, decision-making, and empathy (Wingenfeld and Otte, 2019; Joels, 2018; Chumak et al., 2016), and that GR activation is predicted to play in memory deficits, cognitive decline, and psychopathologies including Alzheimer’s disease (Finsterwald and Alberini, 2014; Ouanes and Popp, 2019; Johnson et al., 2021), make MR and GR most attractive candidates for positive and negative “precognitive” cochlear processing during auditory perception and auditory cognitive dysfunction (Johnson et al., 2021).