Overall, the roles that MR activation is predicted to play in attention, decision-making, and empathy (Wingenfeld and Otte, 2019; Joels, 2018; Chumak et al., 2016), and that GR activation is predicted to play in memory deficits, cognitive decline, and psychopathologies including Alzheimer’s disease (Finsterwald and Alberini, 2014; Ouanes and Popp, 2019; Johnson et al., 2021), make MR and GR most attractive candidates for positive and negative “precognitive” cochlear processing during auditory perception and auditory cognitive dysfunction (Johnson et al., 2021). The gene discussed is NR3C2; the disease is early-onset autosomal dominant Alzheimer disease.