The FBXW7-185aa encoded by circ-FBXW7 can inhibit the proliferation and cell cycle acceleration of glioma (Yang et al., 2018), and the circular SHPRH as well as circular AKT3 could encode tumor-suppressed peptides in glioblastoma (Zhang et al., 2018; Xia et al., 2019). The gene discussed is AKT3; the disease is central nervous system cancer.