A total of 42 interrelationships between active ingredients of CRP and myocardial hypertrophy targets were obtained, and the critical components of CRP to inhibit myocardial hypertrophy were selected according to the parameters of Betweenness Centrality (BC), Closeness Centrality (CC), and Degree Centrality (DC). The gene discussed is CRP; the disease is cardiac hypertrophy.