NFKB1 and asthma: Although IL-4/IL-13 were considered to play a role in allergic asthma mainly through the janus tyrosine kinases JAK1 and JAK3/signal transducer and activator of transcription-6 (STAT6) signaling, studies have shown that in addition to the JAK/STAT signaling, IL-4/IL-13 may also participate in the pathological process of asthma through other pathways such as NF-κB signaling [12].