The most frequent cause of this clinical disorder is the mutation in WDR62 (WD repeat-containing protein 62) and ASPM (abnormal spindle-like, microcephaly-associated) genes which together responsible for more than half (1⁄2) the cases of MCPH, followed by MCPH1 which is the first and third most common causes of MCPH [9–11]. The gene discussed is MCPH1; the disease is autosomal recessive primary microcephaly.