Compared with the BCMI Q2 ∼ Q4 groups, the BCMI Q1 group had the highest prevalence of cognitive impairment, higher age, dialysis age, water load, fat tissue index, while MMSE score, predialysis BMI, postdialysis BMI, dry weight, extracellular water, lean tissue index, muscle mass, albumin, and serum creatinine were lower, and there were fewer male patients, the difference was statistically significant (P < 0.05). The gene discussed is ALB; the disease is Cognitive impairment.