Comparison of clinical characteristics between patients with normal cognitive function and patients with cognitive impairment after PSM: compared with the normal cognitive function group, the cognitive impairment group had lower dry weight, extracellular water, lean tissue index, muscle mass, body mass index, albumin, and serum creatinine, but higher dialysis age, water load, and fat tissue index, all differences were statistically significant (P < 0.05), there was no significant difference in hemoglobin between the two groups (P > 0.05) (Table 3). This evidence concerns the gene ALB and Cognitive impairment.