The immunoinflammatory phenotype is characterized by the presence of a large number of CD4 and CD8 T cells in the tumor parenchyma, usually accompanied by myeloid cells and monocytes; the immune rejection phenotype has obvious immune rejection reactions, characterized by the presence of more immune cells, but these immune cells can only stay in the matrix surrounding the tumor cell nest and cannot penetrate the tumor tissue; the immune desert phenotype refers to the absence of immune cell infiltration, which is characterized by the lack of T cells in the tumor tissue or matrix. The gene discussed is CD4; the disease is neoplasm.