In addition, certain factors have been identified in the occurrence and progression of BC, including Erb-B2 receptor tyrosine kinase 2, avian myelocytomatosis viral oncogene homolog (MYC), cyclin D1, and hypoxia-inducible factor 1α (HIF-1α), that are important for clinical applications [6, 10]. The gene discussed is HIF1A; the disease is breast cancer.