TARDBP and frontotemporal dementia: TDP-43 possesses motifs facilitating mitochondrial import and localizes to the inner mitochondrial membrane in FTD patients, mostly to the cristae of cortical neurons’ mitochondria, blocking the targeting of TDP-43 to mitochondria ameliorated the neurodegenerative phenotype of TDP-43 overexpression mouse models (Wang et al., 2016).