Notably, FUS knockout mice have no motor neuron defects and mutations in FUS have only rarely been found in FTD-FUS (Seelaar et al., 2010; Huey et al., 2012; Sharma et al., 2016), although they are relatively common in familial ALS (Blair et al., 2010; Mejzini et al., 2019). The gene discussed is FUS; the disease is frontotemporal dementia.