TARDBP and Pick disease: FTLD has diverse pathological conditions and is classified mainly into FTLD-tau (corticobasal degeneration, progressive supranuclear palsy, and Pick’s disease), FTLD-trans-activating response region (TAR) DNA-binding protein with a molecular mass of 43 kDa (TDP-43) (FTLD-TDP), and FTLD-fused sarcoma (FTLD-FUS) based on the protein composition of the neuronal and glial inclusions (Mackenzie et al., 2010).