SLC6A3 and Pick disease: Yokota et al. (2009) compared neuronal loss in the substantia nigra, caudate, and putamen between Pick’s disease and FTLD-TDP, including FTLD-TDP type B. They revealed that FTLD-TDP was characterized by more severe neuronal loss in these regions than Pick’s disease (Yokota et al., 2009). In addition, the same researchers showed the preservation of nigral neurons in Pick’s disease (Yokota et al., 2002). Based on these findings (Yokota et al., 2002, 2009), Pick’s disease may be the most unlikely abnormal finding in DAT imaging among patients with FTLD.