A missense mutation (G2019S) within LRRK2 modifies α-synuclein pathology in a mouse PD model and increases kinase GTPase activity to inhibit autophagy and augment the pro-inflammatory response in mouse models of colitis (Takagawa et al., 2018; Bieri et al., 2019). The gene discussed is LRRK2; the disease is Parkinson disease.