NLRP3 and colitis: Dextran sulfate sodium (DSS)-induced colitis caused amyloid plaque accumulation, compromised glymphatic clearance and increased infiltration of gut-derived T-cells, and triggered cortical and hippocampal degeneration mediated by NACHT-LRR and PYD-containing protein 3 (NLRP3) inflammasome expression (He et al., 2021).