As mentioned above, a recent multicenter cohort study investigating maximal resection of CE and NCE tumors demonstrated that in addition to the survival benefit conferred by maximal resection of the CE tumor, additional resection of NCE tumor leads to improved overall survival (OS) regardless of isocitrate dehydrogenase (IDH) and O6-methylguanine-DNA methyltransferase (MGMT) methylation status in younger patients (Molinaro et al., 2020). This evidence concerns the gene IDH1 and neoplasm.