CYBB and viral infectious disease: Although Nox2 is a phagocytic enzyme playing a role in killing bacteria and fungi, it is also known for contributing to virus-induced ROS production during viral infections, e.g., with IV (Influenza virus) [111], HRSV [91], HRV (human rhinovirus) [112], SARS-CoV-2 [37], and SeV (sendai virus) [91, 92].