HMOX1 and pulmonary fibrosis: In order to clarify the mechanism of LMWF regulating pulmonary fibrosis in mice through antioxidant effects, we studied the expression of Nrf-2 and its regulated HO-1, NQO1, and ROS proteins by immunofluorescence, Western blotting, and immunohistochemistry (Figures 6(a)–6(c)).