PROS1 and central nervous system cancer: It has been shown that inhibition of STAT3 activity results in suppression of antiapoptotic proteins (Survivin, Bcl-xL, and Bcl-2) and cell cycle-regulating proteins (c-Myc, cyclin D1, and cyclin E) expression [28], and ascochlorin was found to suppress glioma cell migration and invasion through inhibiting MMP-2 expression by targeting the JAK2/STAT signaling pathway [29].