In addition to regulating a diverse set of viruses, KAP1 has been implicated in a variety of host biological processes including innate immunity, tumor microenvironment regulation, and immune cell development, among others (Czerwinska et al., 2020; Lee et al., 2020; Liang et al., 2020; Liu et al., 2020; Chikuma et al., 2021; Park et al., 2021) (Figure 3). This evidence concerns the gene TRIM28 and neoplasm.