TRIM28 and lung cancer: Using reconstitution assays in A549 lung cancer cells upon IAV infection, the authors showed that KAP1 knockout using CRISPR-Cas9 led to decreased viral replication, and that KAP1, but not KAP1 mutated at 6 Lysine residues capable of getting SUMOylated (named SUMO mutant), could rescue replication levels upon KAP1 loss, suggesting that SUMOylation is critical for productive IAV infection.