They observed that ectopic expression of ZBRK1 into HEK293T cells decreased HIV-1 reporter activity without stimulation, diminished synthesis of viral products (p24) from transfected NL4.3 and that shRNA-mediated ZBRK1 silencing conversely induced reporter activity in HEK293T cells and synthesis of viral products (p24) upon infection of MT-4 cells with NL4.3 virus. The gene discussed is ZNF350; the disease is infection.