Aspergillus flavus was reported to be involved in the production of aflatoxin, targeting aryl hydrocarbon receptor to mediate the expression of P450 to induce hepatocellular carcinoma process, indicating that these species seemed to have an underestimated relation with colorectal cancer (Sharma et al., 2021; Zhu et al., 2021a). This evidence concerns the gene AHR and hepatocellular carcinoma.